CURRICULUM VITAE 

Ying-Jay Liou, M.D.

I.       Personal Information: 

II.     Education： 

III.   Position: 

IV.  Research Interest:

1.     Schizophrenia and Genetics

2.     Psychopharmacology

3.     Pharmacogenomics in Psychiatry

4.     Behavioral science

V.    Invited Journal Reviewer

1.     Neuropsychobiology (SCI)

2.     Acta Pharmacologica Sinica (SCI)

3.     American Journal of Medical Genetics (SCI)

4.     Progress in Neuro-Psychopharmacology & Biological Psychiatry (SCI)

5.     Pharmacogenomics and Genomics (SCI).

6.     Psychiatry Research (SCI).

VI.  Journal Article (*correspondence author)：

1.      Liou YJ, Tsai SJ, Hong CJ, Wang YC, Lai IC. Association analysis of a functional catechol-o-methyltransferase gene polymorphism in schizophrenic patients in Taiwan. Neuropsychobiology. 2001;43(1) 11-14. (SCI, 2007 Impact factor = 1.992)

2.      Liou YJ, Lai IC, Hong CJ, Liu HC, Liu TY, Tsai SJ. Association Analysis of the Partially Duplicated alpha7 Nicotinic Acetylcholine Receptor Genetic Variant and Alzheimer's Disease. Dement Geriatr Cogn Disord. 2001 Sep-Oct;12(5):301-4. (SCI, 2007 Impact factor = 2.641).

3.      Tsai SJ, Cheng CY, Shu LRR, Yang CY, Pan CW, Liou YJ, Hong CJ. No association for D2 and D4 dopamine receptor polymorphisms and methamphetamine abuse in Chinese males. Psychiatric Genetics 2002;12:29-33. (SCI, 2007 Impact factor = 2.257)

4.      Tsai SJ, Yu YW, Chen TJ, Chen JY, Liou YJ, Chen MC, Hong CJ. Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females. Neurosci Lett. 2003 Feb 27;338(2):123-6. (SCI, 2007 Impact factor = 2.085)

5.      Yu YW, Chen TJ, Wang YC, Liou YJ, Hong CJ, Tsai SJ. Association analysis for neuronal nitric oxide synthase gene polymorphism with major depression and fluoxetine response. Neuropsychobiology. 2003;47(3):137-40. (SCI, 2007 Impact factor = 1.992)

6.      Liou YJ, Chen YS. Selective Serotonin Reuptake Inhibitor (SSRI) Discontinuation Syndrome. Taiwanese J Psychiatry 2003;17:64-70. (Chinese)

7.      Chiu HJ, Wang YC, Liou YJ, Lai IC, Chen JY. Association Analysis of the Genetic Variants of the N-Methyl D-Aspartate Receptor Subunit 2b (NR2b) and Treatment-Refractory Schizophrenia in the Chinese. Neuropsychobiology. 2003;47(4):178-81. (SCI, 2007 Impact factor = 1.992)

8.      Liou YJ, Tsai SJ, Hong CJ, Liao DL. Association analysis for the CA repeat polymorphism of the neuronal nitric oxide synthase (NOS1) gene and schizophrenia. Schizophrenia Res. 2003 Dec 1;65(1):57-9 (SCI, 2007 Impact factor = 4.240)

9.      Liou YJ, Wang YC, Bai YM, Lin CC, Yu SC, Liao DL, Ling MW, Chen JY, Lai IC. Cytochrome P450 2D6*10 C188T Polymorphism Is Associated with Antipsychotics-induced Persistent Tardive Dyskinesia in Chinese Schizophrenic Patients. Neuropsychobiology. 2004;49(4):167-73. (SCI, 2007 Impact factor = 1.992)

10.   Wang YC, Liou YJ, Liao DL, Bai YM, Lin CC, Yu SC, Chen JY. Association analysis of a neural nitric oxide synthase gene polymorphism and antipsychotics-induced tardive dyskinesia in Chinese schizophrenic patients. J Neural Transm. 2004 May;111(5):623-9. (SCI, 2007 Impact factor = 2.672)

11.   Tsai SJ, Hong CJ, Liao DL, Lai IC, Liou YJ. Association Study of a functional catechol-o-methyltransferase genetic polymorphism with age of onset, cognitive function, symptomatology and prognosis in chronic schizophrenia. Neuropsychobiology. 2004;49(4):196-200. (SCI, 2007 Impact factor = 1.992)

12.   Liou YJ, Liao DL, Chen JY, Wang YC, Lin CC, Bai YM, Yu SC, Lin MW, Lai IC. Association analysis of the dopamine D3 receptor gene ser9gly and brain-derived neurotrophic factor gene val66met polymorphisms with antipsychotic-induced persistent tardive dyskinesia and clinical expression in Chinese schizophrenic patients. Neuromol Med. 2004;5(3):243-52 (SCI, 2007 Impact factor = 2.483)

13.   Lai IC, Wang YC, Lin CC, Bai YM, Liao DL, Yu SC, Lin CY, Chen JY, Liou YJ *. Negative association between Catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and Persistent Tardive Dyskinesia in Schizophrenia. J Neural Transm. 2005 Aug;112(8):1107-13. (SCI, 2007 Impact factor = 2.672)

14.   Liou YJ, Wang YC, Lin CC, Bai YM, Lai IC, Liao DL, Chen JY. Association analysis of NAD(P)H: quinone oxidoreductase (NQO1) Pro187Ser genetic polymorphism and tardive dyskinesia in patients with schizophrenia in Taiwan. Int J Neuropsychopharmacol. 2005 Sep;8(3):483-6. (SCI, 2007 Impact factor = 4.895)

15.   Lai IC, Liou YJ, Chen JY, Wang YC. No Association between the Ionotropic Glutamate Receptor Kainate 3 Gene ser310ala Polymorphism and Schizophrenia. Neuropsychobiology. 2005;51(4):211-3. (SCI, 2007 Impact factor = 1.992)

16.   Wang YC, Bai YM, Chen JY, Lin CC, Lai IC, Liou YJ *. Polymorphism of the adrenergic receptor alpha 2a –1291C>G genetic variation and clozapine-induced weight gain. J Neural Transm. 2005 Nov;112(11):1463-8. (SCI, 2007 Impact factor = 2.672)

17.   Wang YC, Bai YM, Chen JY, Lin CC, Lai IC, Liou YJ *. C825T Polymorphism in human G protein beta3 subunit gene is associated with long-term clozapine treatment induced body weight change in Chinese Population. Pharmacogenet Genomics. 2005 Oct;15(10):743-748. (SCI, 2007 Impact factor = 5.772)

18.   Liou YJ, Lai IC, Lin MW, Bai YM, Lin CC, Liao DL, Chen JY, Lin CY, Wang YC. Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and tardive dyskinesia in patients with schizophrenia. Pharmacogenet Genomics. 2006 Mar;16(3):151-157. (SCI, 2007 Impact factor = 5.772)

19.   Tsai SJ, Hong CJ, Liu HC, Liu TY, Liou YJ. The BDNF Gene may be a Susceptibility Candidate for Alzheimer’s Disease in a Chinese Population. Dement Geriatr Cogn Disord. 2007;21(3):139-43. (SCI, 2007 Impact factor = 2.641).

20.   Yu YWY, Tsai SJ, Liou YJ, Hong CJ, Chen TJ. Association study of two serotonin 1A receptor gene polymorphisms and fluoxetine treatment response in Chinese major depressive disorders. Eur Neuropsychopharmacol 2006 Oct;16(7):498-503. (SCI, 2007 Impact factor = 4.430).  

21.   Tsai SJ, Cheng CY, Hong CJ, Liao DL, Hou SJ, Yen FC, Liou YJ. Association study of polymorphisms in glycine transporter with schizophrenia. J Neural Transm 2006 Oct;113(10):1545-9. (SCI, 2007 Impact factor = 2.672).

22.   Liou YJ, Lai IC, Wang YC, Bai YM, Lin CC, Lin CY, Chen TT, Chen JY. Genetic analysis of the human ENTH (Epsin 4) gene and schizophrenia. Schizophr Res 2006 Jun;84(2-3):236-43. (SCI, 2007 Impact factor = 4.240).

23.   Liou YJ, Lai IC, Liao DL et al. The human dopamine receptor D2 (DRD2) gene is associated with tardive dyskinesia in patients with schizophrenia. Schizophr Res 2006 Sep;86(1-3):323-5. (SCI, 2007 Impact factor = 4.240).

24.   Hong CJ, Hou SJ, Yen FC, Liou YJ, Tsai SJ. Family-based association study between the G72/G30 genetic polymorphism and schizophrenia. NeuroReport 2006 Jul 17;17(10):1067-9. (SCI, 2007 Impact factor = 2.163).

25.   Tsai SJ, Hong CJ, Cheng CY, Liao DL, Liou YJ. Association study of polymorphisms in post-synaptic density protein 95 (PSD-95) with schizophrenia J Neural Transm 2007 Apr;114(4):423-6.

26.   Chen SF, Chen JY, Wang YC, Lai IC, Liou YJ, Liao DL, Chen CH. Support for association of the A277C single nucleotide polymorphism in human vesicular monoamine transporter 1 gene with schizophrenia Schizophr Res 2007 Feb;90(1-3):363-5 (SCI, 2007 Impact factor = 4.240).

27.   Tsai SJ, Liou YJ, Liao DL, Cheng CY, Hong CJ. No association of GRIP1 gene polymorphisms with schizophrenia in Chinese population. Prog Neuropsychopharmacol Biol Psychiatry 2007 Apr 13;31(3):752-5 (SCI, 2007 Impact factor = 2.802).

28.   Tsai SJ, Hong CJ, Liou YJ, Liao DL. Association Study of GOT2 genetic polymorphisms and schizophrenia. Psychiatr Genet 2007 Oct;17(5):314. (SCI, 2007 Impact factor = 2.257).

29.   Mo GH, Liao DL, Lai IC, Wang YC, Chen JY, Lin CY, Chen TT, Chen ML, Bai YM, Lin CC, Liou YJ*. Support for an association of the C939T polymorphism in the human DRD2 gene with tardive dyskinesia in schizophrenia. Schizophrenia Res 2007 Dec; 97 (1-3): 302-4 (SCI, 2007 Impact factor = 4.240).

30.   Liou YJ, Wang YC, Chen JY et al. Association analysis of polymorphisms in the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia. Psychiatry Res 2007 Dec 3;153(3):271-5. (SCI, 2007 Impact factor = 2.298).

31.   Hong CJ, Liou YJ, Liao DL, Hou SJ, Yen FC, Tsai SJ. Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2007 Oct 1;31(7):1510-3. (SCI, 2007 Impact factor = 2.802).

32.   Wu MK, Huang CY, Liou YJ, Wang CK, Lee SD. Glucose-insulin homeostasis, lipid profiles and GH-IGF-IGFBP axis in clozapine-treated schizophrenic obesity versus non-psychiatric obesity. Int J Obesity 2008 Mar;32(3):436-42. (SCI, 2007 Impact factor = 4.055) (in press)

33.   Gau YT, Liou YJ, Yu YWY, Chen TJ, Lin MW, Tsai SJ, Hong CJ. Evidence for Association between Genetic Variants of p75 neurotrophin receptor (p75^NTR) Gene and Antidepressant Treatment Response in Chinese Major Depressive Disorder. Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):594-9 (SCI, 2007 Impact factor = 4.224) (Gau and Liou contributed equally to the work).

34.   Lin CC, Bai YM, Chen JY, Wang YC, Liou YJ. Treatment of clozapine-associated tardive dyskinesia. Prog Neuropsychopharmacol Biol Psychiatry (in press) (SCI, 2007 Impact factor = 2.802).

35.   Tsai SJ, Liou YJ, Hong CJ, Yu YWY, Chen TJ. Glycogen synthase kinase-3 beta gene is associated with antidepressant treatment response in Chinese major depressive disorder. Pharmacogneomics J 2008 Dec;8(6):384-90. (SCI, 2007 Impact factor = 4.968) (Tsai and Liou contributed equally to the work).  

36.   Tsai SJ, Hong CJ, Liou YJ, Chen TJ, Chen ML, Yu YWY. Haplotype analysis of single nucleotide polymorphisms in the vascular endothelial growth factor (VEGF) gene and antidepressant treatment response in major depressive disorder. Psychiatry Res (In press).

37.   Tsai SJ, Gau TA, Liu ME, Hsieh CH, Liou YJ, Hong CJ. Association study of brain-derived neurotrophic factor and apolipoprotein E polymorphisms and cognitive function in aged males with dementia. Neurosci Lett 2008 Mar 12;433(2):158-62. (SCI)

38.   Wang LH, Chen JY, Liou YJ, Wang YC, Lai IC, Liao DL, Chen CH. Association of missense variants of the PRKC, apoptosis, WTI, regulator (PAWR) gene with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):870-5. (SCI).

39.   Bai YM, Chen JY, Yang WC, Chi YC, Liou YJ, Lin CC, Wang YC, Lin CY, Su TP, Chou P. Adiponectin as a potential biomarker for the metabolic syndrome in Chinese patients taking clozapine for schizophrenia. J Clin Psychiatry 2007 Dec;68(12):1834-9. (SCI).

40.   Tsai SJ, Gau YT, Liu ME, Hsieh CH, Liou YJ, Hong CJ. Association study of brain-derived neurotrophic factor and apolipoprotein E polymorphisms and cognitive function in aged males without dementia. Neurosci Lett. 2008 Mar 12;433(2):158-62. (SCI).

41.   Liu ME, Hong CJ, Liou YJ, Tsai YL, Hsieh CH, Tsai SJ. Association study of a functional catechol-O-methyltransferase polymorphism and executive function in elderly males without dementia. Neurosci Lett. 2008 May 9;436(2):193-5. (SCI, 2007 Impact factor = 2.085).

42.   Tsai SJ, Gau TA, Hong CJ, Liou YJ, Yu YWY, Chen TJ. Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism on clinical response to fluoxetine in major depressive patients. J Affect Disord (In press). 

43.   Liou YJ, Chen ML, Wang YC, Chen JY, Liao DL, Bai YM et al. Analysis of genetic variations in the human Par-4 (PAWR) gene and tardive dyskinesia in schizophrenia. Am J Med Genet (In press) (SCI, 2007 Impact factor = 4.224).

44.   Liou YJ, Chen ML, Wang YC et al. Analysis of genetic variants in the RGS9 gene and antipsychotics-induced tardive dyskinesia in schizophrenia. Am J Med Genet 2009 Mar 5;150B(2):239-42. (SCI, 2007 Impact factor = 4.224).

45.   Tsai SJ, Hong CJ, Liou YJ, Yu YWY, Chen TJ. Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response. Pharmacogenet Genomics 2008 Oct;18(10):869-875. (SCI, 2007 Impact factor = 5.772).

46.   Lin CC, Chen JY, Wang YC, Liou YJ et al. Artificial neural network prediction of clozapine response with combined pharmacogenetic and clinical data. Comput Methods Programs Biomed. 2008 Aug;91(2):91-9. (SCI).

47.   Tsai SJ, Hong CJ, Liou YJ. Brain-derived neurotrophic factor and antidepressant action: Another piece of evidence from pharmacogenetic study. Pharmacogenomics 2008 Sep;9(9):1353-8. (SCI).

48.   Wang YC, Chen ML, Chen JY, Chen CH, Lai IC, Chen TT, Hong CJ, Tsai SJ, Liou YJ*. Neuregulin 3 (NRG3) genetic variations and susceptibility to schizophrenia in a Chinese population. Biol Psychiatry 2008 Dec 15;64(12):1093-6. (SCI, 2007 Impact factor = 8.456)

49.   Liou YJ, Wang YC, Chen JY et al. The coding-synonymous polymorphism rs1045280 (Ser280Ser) in β-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia. Eur J Neurology 2008 Dec;15(12):1406-8. (SCI, 2007 Impact factor = 2.580).

50.   Chao YL, Shen YC, Laio DL, Chen JY, Wang YC, Lai IC, Liou YJ, Chen CH. Association study of HLA-A gene and schizophrenia in Han Chinese from Taiwan. Prog Neuropsychopharmacol Biol Psychiatry 2008 Dec 12;32(8):1834-7. (SCI, 2007 Impact factor = 2.802).

51.   Tsai SJ, Hong CJ, Liu ME, Hou SJ, Yen FC, Hsieh CH, Liou YJ. Interleukin-1 beta (C-511T) genetic polymorphism is associated with cognitive performance in elderly males without dementia. Neurobiol Aging (In Press).

52.   Tzang RF, Hong CJ, Liou YJ, Younger YWY, Chen TJ, Tsai SJ. Association study of p11 gene with major depressive disorder, suicidal behaviors and treatment response. Neurosci Lett Dec 5;447(1):92-5. (SCI)

53.   Tsai SJ, Hong CJ, Liou YJ, Younger YWY, Chen TJ, Hou CJ, Yen FC. Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response. Prog Neuropsychopharmacol Biol Psychiatry (In Press).

54.   Liou YJ, Chen TJ, Tsai SJ, Yu YWY, Cheng CY, Hong CJ. Support for the involvement of the KCNK2 gene in major depressive disorder and response to antidepressant treatment. (In revision).  

Updated on 2009/03/19