蔡世仁 醫師 (Shih-Jen Tsai, M. D.) (1961 - ? )
1. Christian.
2. One daughter and one son.
3. Chairman, Department of Psychiatry, Taipei Veteran General Hospital, Taipei, Taiwan.
4. Professor, Psychiatric Division, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Editorial Board of the Journal:
1). Medical Science Monitor
2). Taiwanese Journal of Psychiatry
3). Life
4). Current Psychiatry Research and Reviews
Postdoctoral Fellow: Psychiatry Department, University of California, San Francisco (2004.7~2005.6)
Education: M.D. School of Medicine, National Yang Ming University, Taipei, Taiwan (1979.9~1986.6)
Research Topic: Biological Psychiatry (Psychopharmacology; Molecular Psychiatry; Geriatric Psychiatry; Neuroimage).
Google Scholar: h-index 66, citations: 16,148 (February 2, 2021)
https://scholar.google.com.tw/citations?user=pfWHCtUAAAAJ&hl=zh-TW&oi=ao
Book Chapters:
1. Tsai SJ, Lee TW. Schizophrenia, suicide and the role of serotonin. In Pompili M, et al., ed. Suicide in Schizophrenia. Nova Science Publishers, Inc. (2007).
2. Wang PN, Tsai SJ, Liu HC. Neuropsychological Manifestations in Preclinical Alzheimer’s Disease. In Columbus F, ed. Focus on Alzheimer’s Disease Research. Nova Science Publishers, Inc. (2007).
3. Lin E, Tsai SJ. Genetics and Suicide. In Philippe Courtet, ed. Understanding Suicide from Diagnosis to Personalized Treatment. Springer Publishers, Inc. (2016).
4. Lin E, Tsai SJ. Machine learning and predictive algorithms for personalized medicine: from physiology to treatment. In: Turnbull A, editor. Personalized Medicine. New York: Nova Science Publisher, Inc. (2016).
5. Lin E, Tsai SJ. Diagnostic prediction based on gene expression profiles and artificial neural networks. In Hemant J Purohit, ed. Soft computing in biological sciences. Springer Publishers, Inc. (2017).
6. Lin E, Tsai SJ. Gene-Environment Interactions and Role of Epigenetics in Depression. In Yong-Ku Kim, ed. Understanding Depression. Springer Publishers, Inc. (2018).
7. Chen MH, Tsai SJ. Treatment resistance in panic disorder. In Yong-Ku Kim, ed. Treatment Resistance in Psychiatry. Springer Publishers, Inc. (2019).
8. Chen MH, Su TP, Tsai SJ. ketamine and other glutamate receptor antagonists as fast-acting antidepressants: Evidence from translational research. In Yong-Ku Kim, ed. Translational Research Methods for Major Depressive Disorder. Springer Publishers, Inc. (2021).
Refereed Papers: (February 2, 2021)
1. Zhang Y, Luo Q, Huang CC, Lo CZ, Langley C, Desrivières S, Quinlan EB, Banaschewski T, Millenet S, Bokde ALW, Flor H, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Paillère-Martinot ML, Nees F, Orfanos DP, Poustka L, Fröhner JH, Smolka MN, Walter H, Whelan R, Tsai SJ, Lin CP, Bullmore E, Schumann G, Sahakian BJ, Feng J (2021) The Human Brain Is Best Described as Being on a Female/Male Continuum: Evidence from a Neuroimaging Connectivity Study. Cerebral cortex (New York, NY : 1991). doi:10.1093/cercor/bhaa408
2. Zhang B, Wang HE, Bai YM, Tsai SJ, Su TP, Chen TJ, Wang YP, Chen MH (2021) Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study. Gut 70 (1):85-91. doi:10.1136/gutjnl-2020-320789
3. Tsai SJ (2021) Role of interleukin 8 in depression and other psychiatric disorders. Progress in neuro-psychopharmacology & biological psychiatry 106:110173. doi:10.1016/j.pnpbp.2020.110173
4. Tsai HJ, Yang WC, Tsai SJ, Lin CH, Yang AC (2021) Remission of depression is associated with asymmetric hemispheric variation in EEG complexity before antidepressant treatment. Journal of affective disorders 281:872-879. doi:10.1016/j.jad.2020.11.041
5. Tsai HJ, Kuo TBJ, Yang AC, Tsai SJ, Yang CCH (2021) Difficulty in initiating sleep is associated with poor morning cardiovascular function. Psychiatry research 295:113518. doi:10.1016/j.psychres.2020.113518
6. Liu MN, Yeh HL, Kuan AS, Tsai SJ, Liou YJ, Walsh V, Lau CI (2021) High-Frequency External Muscle Stimulation Reduces Depressive Symptoms in Older Male Veterans: A Pilot Study. Journal of geriatric psychiatry and neurology 34 (1):37-45. doi:10.1177/0891988720915524
7. Huang KL, Hsu JW, Tsai SJ, Bai YM, Chen TJ, Chen MH (2021) Factors Affecting Delayed Initiation and Continuation of Medication Use for Attention-Deficit/Hyperactivity Disorder: A Nationwide Study. Journal of child and adolescent psychopharmacology. doi:10.1089/cap.2020.0136
8. Huang JS, Yang FC, Chien WC, Yeh TC, Chung CH, Tsai CK, Tsai SJ, Yang SS, Tzeng NS, Chen MH, Liang CS (2021) Risk of Substance Use Disorder and Its Associations With Comorbidities and Psychotropic Agents in Patients With Autism. JAMA pediatrics 175 (2):e205371. doi:10.1001/jamapediatrics.2020.5371
9. Hua MH, Chen MH, Hsu JW, Huang KL, Tsai SJ, Li CT, Bai YM (2021) Proinflammatory Cytokine Dysregulation and Cognitive Dysfunction Among Patients with Remitted Bipolar I and II Disorders. Journal of affective disorders 281:738-743. doi:10.1016/j.jad.2020.11.079
10. Chu HT, Cheng CM, Liang CS, Chang WH, Juan CH, Huang YZ, Jeng JS, Bai YM, Tsai SJ, Chen MH, Li CT (2021) Efficacy and tolerability of theta-burst stimulation for major depression: A systematic review and meta-analysis. Progress in neuro-psychopharmacology & biological psychiatry 106:110168. doi:10.1016/j.pnpbp.2020.110168
11. Chen MH, Wu HJ, Li CT, Lin WC, Bai YM, Tsai SJ, Hong CJ, Tu PC, Cheng CM, Su TP (2021) Using classification and regression tree modelling to investigate treatment response to a single low-dose ketamine infusion: Post hoc pooled analyses of randomized placebo-controlled and open-label trials. Journal of affective disorders 281:865-871. doi:10.1016/j.jad.2020.11.045
12. Chen MH, Pan TL, Lin WC, Huang KL, Hsu JW, Li CT, Tsai SJ, Su TP, Chen TJ, Bai YM (2021) Bidirectional association between migraine and depression among probands and unaffected siblings: A nationwide population-based study. Journal of affective disorders 279:687-691. doi:10.1016/j.jad.2020.10.056
13. Chen MH, Lin WC, Wu HJ, Bai YM, Li CT, Tsai SJ, Hong CJ, Tu PC, Su TP (2021) Interest-activity symptom severity predicts response to ketamine infusion in treatment-resistant depression. Psychopharmacology. doi:10.1007/s00213-020-05737-z
14. Zhao W, Guo S, Linli Z, Yang AC, Lin CP, Tsai SJ (2020) Functional, Anatomical, and Morphological Networks Highlight the Role of Basal Ganglia-Thalamus-Cortex Circuits in Schizophrenia. Schizophrenia bulletin 46 (2):422-431. doi:10.1093/schbul/sbz062
15. Liu MN, Liou YJ, Wang WC, Su KC, Yeh HL, Lau CI, Hu LY, Tsai SJ, Chen HY. Group Music Intervention Using Percussion Instruments to Reduce Anxiety Among Elderly Male Veterans with Alzheimer Disease. Med Sci Monit 2021; 27:e928714 :: DOI: 10.12659/MSM.928714
16. Xie W, Peng CK, Shen J, Lin CP, Tsai SJ, Wang S, Chu Q, Yang AC (2020) Age-related changes in the association of resting-state fMRI signal variability and global functional connectivity in non-demented healthy people. Psychiatry research 291:113257. doi:10.1016/j.psychres.2020.113257
17. Wang SH, Lai RY, Lee YC, Su MH, Chen CY, Hsiao PC, Yang AC, Liu YL, Tsai SJ, Kuo PH (2020) Association between polygenic liability for schizophrenia and substance involvement: A nationwide population-based study in Taiwan. Genes, brain, and behavior 19 (5):e12639. doi:10.1111/gbb.12639
18. Wang HE, Cheng CM, Bai YM, Hsu JW, Huang KL, Su TP, Tsai SJ, Li CT, Chen TJ, Leventhal BL, Chen MH (2020) Familial coaggregation of major psychiatric disorders in first-degree relatives of individuals with autism spectrum disorder: a nationwide population-based study. Psychological medicine:1-11. doi:10.1017/s0033291720003207
19. Tsai SJ (2020) Preventive potential of low intensity pulsed ultrasound for chronic traumatic encephalopathy after repetitive head collisions in contact sports. Medical hypotheses 134:109422. doi:10.1016/j.mehy.2019.109422
20. Tsai SJ (2020) Salivary gland low-intensity pulsed ultrasound (LIPUS) stimulation as a potential treatment for various BDNF-implicated neuropsychiatric disorders. Medical hypotheses 137:109560. doi:10.1016/j.mehy.2020.109560
21. Tsai SJ (2020) The importance of measuring problematic smartphone use in children with attention deficit hyperactivity disorder. Journal of the Chinese Medical Association : JCMA 83 (9):803-804. doi:10.1097/jcma.0000000000000372
22. Ting EY, Yang AC, Tsai SJ (2020) Role of Interleukin-6 in Depressive Disorder. International journal of molecular sciences 21 (6). doi:10.3390/ijms21062194
23. Ruan H, Luo Q, Palaniyappan L, Lu W, Huang CC, Zac Lo CY, Yang AC, Liu ME, Tsai SJ, Lin CP, Feng J (2020) Topographic diversity of structural connectivity in schizophrenia. Schizophrenia research 215:181-189. doi:10.1016/j.schres.2019.10.034
24. Rolls ET, Cheng W, Gilson M, Gong W, Deco G, Lo CZ, Yang AC, Tsai SJ, Liu ME, Lin CP, Feng J (2020) Beyond the disconnectivity hypothesis of schizophrenia. Cerebral cortex (New York, NY : 1991) 30 (3):1213-1233. doi:10.1093/cercor/bhz161
25. Liu MN, Tsai SJ, Yeh HL, Wu CC, Lin CP (2020) MCP-2/CCL8 Level Associated With Suicidal Ideation in Elderly Men With Major Depression. Archives of suicide research : official journal of the International Academy for Suicide Research 24 (3):467-476. doi:10.1080/13811118.2019.1649772
26. Lin YT, Hsu JW, Huang KL, Tsai SJ, Su TP, Li CT, Lin WC, Chen TJ, Bai YM, Chen MH (2020) Sexually transmitted infections among adolescents with conduct disorder: a nationwide longitudinal study. European child & adolescent psychiatry. doi:10.1007/s00787-020-01605-5
27. Lin WY, Liu YL, Yang AC, Tsai SJ, Kuo PH (2020) Active Cigarette Smoking Is Associated With an Exacerbation of Genetic Susceptibility to Diabetes. Diabetes 69 (12):2819-2829. doi:10.2337/db20-0156
28. Lin WY, Lin YS, Chan CC, Liu YL, Tsai SJ, Kuo PH (2020) Using Genetic Risk Score Approaches to Infer Whether an Environmental Factor Attenuates or Exacerbates the Adverse Influence of a Candidate Gene. Frontiers in genetics 11:331. doi:10.3389/fgene.2020.00331
29. Lin WY, Chan CC, Liu YL, Yang AC, Tsai SJ, Kuo PH (2020) Sex-specific autosomal genetic effects across 26 human complex traits. Human molecular genetics 29 (7):1218-1228. doi:10.1093/hmg/ddaa040
30. Lin SH, Cheng CM, Tsai SJ, Tsai CF, Bai YM, Su TP, Li CT, Lin WC, Chen TJ, Chen MH (2020) A Population-Based, Nationwide Longitudinal Study of Bipolar Disorder With Incident Dementia in Taiwan. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 28 (5):530-541. doi:10.1016/j.jagp.2019.10.016
31. Lin MZ, Tsai SJ, Hsu JW, Huang KL, Chen MH (2020) A child with moyamoya disease: Mimicking the presentation of panic attack. Psychiatry research 285:112720. doi:10.1016/j.psychres.2019.112720
32. Lin E, Tsai SJ (2020) Gene-Environment Interactions and Role of Epigenetics in Anxiety Disorders. Advances in experimental medicine and biology 1191:93-102. doi:10.1007/978-981-32-9705-0_6
33. Lin E, Kuo PH, Liu YL, Yu YW, Yang AC, Tsai SJ (2020) Prediction of Antidepressant Treatment Response and Remission Using an Ensemble Machine Learning Framework. Pharmaceuticals (Basel, Switzerland) 13 (10). doi:10.3390/ph13100305
34. Lin CY, Tsai SJ, Peng CK, Yang AC (2020) Sleep state instabilities in patients with periodic limb movements in sleep - Detection and quantification with heart rate variability. Psychiatry research 293:113454. doi:10.1016/j.psychres.2020.113454
35. Liang CS, Bai YM, Hsu JW, Huang KL, Ko NY, Chu HT, Yeh TC, Tsai SJ, Chen TJ, Chen MH (2020) The Risk of Sexually Transmitted Infections Following First-Episode Schizophrenia Among Adolescents and Young Adults: A Cohort Study of 220 545 Subjects. Schizophrenia bulletin 46 (4):795-803. doi:10.1093/schbul/sbz126
36. Li JR, Tsai SJ, Bai YM, Hsu JW, Huang KL, Su TP, Li CT, Lin WC, Chen TJ, Pan TL, Chen MH (2020) Cardiometabolic disease risk among siblings of patients with major depressive disorder. Journal of developmental origins of health and disease:1-6. doi:10.1017/s2040174420000860
37. Li CY, Dai YX, Chang YT, Bai YM, Tsai SJ, Chen TJ, Chen MH (2020) Proton pump inhibitors are associated with increased risk of alopecia areata: A nationwide nested case-control study. Journal of the American Academy of Dermatology 83 (5):1460-1462. doi:10.1016/j.jaad.2020.02.076
38. Li CT, Cheng CM, Chen MH, Juan CH, Tu PC, Bai YM, Jeng JS, Lin WC, Tsai SJ, Su TP (2020) Antidepressant Efficacy of Prolonged Intermittent Theta Burst Stimulation Monotherapy for Recurrent Depression and Comparison of Methods for Coil Positioning: A Randomized, Double-Blind, Sham-Controlled Study. Biological psychiatry 87 (5):443-450. doi:10.1016/j.biopsych.2019.07.031
39. Kuo CY, Lee PL, Hung SC, Liu LK, Lee WJ, Chung CP, Yang AC, Tsai SJ, Wang PN, Chen LK, Chou KH, Lin CP (2020) Large-Scale Structural Covariance Networks Predict Age in Middle-to-Late Adulthood: A Novel Brain Aging Biomarker. Cerebral cortex (New York, NY : 1991) 30 (11):5844-5862. doi:10.1093/cercor/bhaa161
40. Kao CF, Kuo PH, Yu YW, Yang AC, Lin E, Liu YL, Tsai SJ (2020) Gene-Based Association Analysis Suggests Association of HTR2A With Antidepressant Treatment Response in Depressed Patients. Frontiers in pharmacology 11:559601. doi:10.3389/fphar.2020.559601
41. Jeng JS, Li CT, Lin HC, Tsai SJ, Bai YM, Su TP, Chang YW, Cheng CM (2020) Antidepressant-resistant depression is characterized by reduced short- and long-interval cortical inhibition. Psychological medicine 50 (8):1285-1291. doi:10.1017/s0033291719001223
42. Huang MH, Wang YP, Wu PS, Chan YE, Cheng CM, Yang CH, Tsai SJ, Lu CL, Tsai CF (2020) Association between Gastrointestinal Symptoms and Depression Among Older Adults in Taiwan: A Cross-Sectional Study. Journal of the Chinese Medical Association : JCMA. doi:10.1097/jcma.0000000000000460
43. Huang MH, Cheng CM, Tsai SJ, Bai YM, Li CT, Lin WC, Su TP, Chen TJ, Chen MH (2020) Familial coaggregation of major psychiatric disorders among first-degree relatives of patients with obsessive-compulsive disorder: a nationwide study. Psychological medicine:1-8. doi:10.1017/s0033291719003696
44. Huang CC, Luo Q, Palaniyappan L, Yang AC, Hung CC, Chou KH, Zac Lo CY, Liu MN, Tsai SJ, Barch DM, Feng J, Lin CP, Robbins TW (2020) Transdiagnostic and Illness-Specific Functional Dysconnectivity Across Schizophrenia, Bipolar Disorder, and Major Depressive Disorder. Biological psychiatry Cognitive neuroscience and neuroimaging 5 (5):542-553. doi:10.1016/j.bpsc.2020.01.010
45. Hua MH, Huang KL, Hsu JW, Bai YM, Su TP, Tsai SJ, Li CT, Lin WC, Chen TJ, Chen MH (2020) Early Pregnancy Risk Among Adolescents With ADHD: A Nationwide Longitudinal Study. Journal of attention disorders:1087054719900232. doi:10.1177/1087054719900232
46. Hua MH, Chen YL, Chen MH, Huang KL, Hsu JW, Bai YM, Tsai SJ, Wu YT (2020) Network-Specific Corticothalamic Dysconnection in Attention-Deficit Hyperactivity Disorder. Journal of developmental and behavioral pediatrics : JDBP. doi:10.1097/dbp.0000000000000875
47. Hu LY, Yang AC, Lee SC, You ZH, Tsai SJ, Hu CK, Shen CC (2020) Risk of Parkinson's disease following gout: a population-based retrospective cohort study in Taiwan. BMC neurology 20 (1):338. doi:10.1186/s12883-020-01916-9
48. Hou SJ, Yang AC, Tsai SJ, Shen CC, Lan TH (2020) Tinnitus Among Patients With Anxiety Disorder: A Nationwide Longitudinal Study. Frontiers in psychiatry 11:606. doi:10.3389/fpsyt.2020.00606
49. Hou SJ, Tsai SJ, Kuo PH, Liu YL, Yang AC, Lin E, Lan TH (2020) An association study in the Taiwan Biobank reveals RORA as a novel locus for sleep duration in the Taiwanese Population. Sleep medicine 73:70-75. doi:10.1016/j.sleep.2020.04.008
50. Chu HT, Liang CS, Yeh TC, Hu LY, Yang AC, Tsai SJ, Shen CC (2020) Tinnitus and risk of Alzheimer's and Parkinson's disease: a retrospective nationwide population-based cohort study. Scientific reports 10 (1):12134. doi:10.1038/s41598-020-69243-0
51. Cheng CM, Chen MH, Yang CH, Tsai SJ, Tsai CF (2020) Dr Cheng and Colleagues Reply. The Journal of clinical psychiatry 81 (3). doi:10.4088/JCP.19lr13217a
52. Cheng CM, Bai YM, Tsai CF, Tsai SJ, Wu YH, Pan TL, Chen TJ, Chen MH (2020) Risk of Parkinson's disease among patients with herpes zoster: a nationwide longitudinal study. CNS spectrums 25 (6):797-802. doi:10.1017/s1092852919001664
53. Chen MH, Lin WC, Wu HJ, Cheng CM, Li CT, Hong CJ, Tu PC, Bai YM, Tsai SJ, Su TP (2020) Corrigendum to Antisuicidal Effect, BDNF Val66Met Polymorphism, and Low-Dose Ketamine Infusion: Reanalysis of Adjunctive Ketamine Study of Taiwanese Patients with Treatment-Resistant Depression (AKSTP-TRD). J Affect Disord. 2019 May 15;251:162-169. doi: 10.1016/j.jad.2019.03.075. Epub 2019 Mar 23. Journal of affective disorders 274:1217. doi:10.1016/j.jad.2020.05.069
54. Chen MH, Lin WC, Wu HJ, Cheng CM, Li CT, Hong CJ, Tu PC, Bai YM, Tsai SJ, Su TP (2020) Corrigendum to "Cognitive function of patients with treatment-resistant depression after a single low dose of ketamine infusion". J Affect Disord. 2018 Dec 1;241:1-7. doi: 10.1016/j.jad.2018.07.033. Epub 2018 Jul 27. Journal of affective disorders 274:1219. doi:10.1016/j.jad.2020.05.137
55. Chen MH, Lin WC, Wu HJ, Bai YM, Li CT, Tsai SJ, Hong CJ, Tu PC, Cheng CM, Su TP (2020) Efficacy of low-dose ketamine infusion in anxious vs nonanxious depression: revisiting the Adjunctive Ketamine Study of Taiwanese Patients with Treatment-Resistant Depression. CNS spectrums:1-6. doi:10.1017/s1092852920001194
56. Chen MH, Lin WC, Wu HJ, Bai YM, Li CT, Tsai SJ, Hong CJ, Tu PC, Cheng CM, Su TP (2020) Happiness During Low-Dose Ketamine Infusion Predicts Treatment Response: Reexploring the Adjunctive Ketamine Study of Taiwanese Patients With Treatment-Resistant Depression. The Journal of clinical psychiatry 81 (6). doi:10.4088/JCP.20m13232
57. Chen MH, Kao ZK, Chang WC, Tu PC, Hsu JW, Huang KL, Su TP, Li CT, Lin WC, Tsai SJ, Bai YM (2020) Increased Proinflammatory Cytokines, Executive Dysfunction, and Reduced Gray Matter Volumes In First-Episode Bipolar Disorder and Major Depressive Disorder. Journal of affective disorders 274:825-831. doi:10.1016/j.jad.2020.05.158
58. Chen MH, Kao CF, Tsai SJ, Li CT, Lin WC, Hong CJ, Bai YM, Tu PC, Su TP (2020) Treatment response to low-dose ketamine infusion for treatment-resistant depression: A gene-based genome-wide association study. Genomics 113 (2):507-514. doi:10.1016/j.ygeno.2020.12.030
59. Chen MH, Hsu JW, Huang KL, Tsai SJ, Su TP, Li CT, Lin WC, Tu PC, Bai YM (2020) Role of obesity in systemic low-grade inflammation and cognitive function in patients with bipolar I disorder or major depressive disorder. CNS spectrums:1-7. doi:10.1017/s1092852920001534
60. Chen MH, Hsu JW, Huang KL, Tsai SJ, Su TP, Li CT, Lin WC, Tu PC, Bai YM (2020) Role of appetite hormone dysregulation in the cognitive function among patients with bipolar disorder and major depressive disorder. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry:1-7. doi:10.1080/15622975.2020.1819566
61. Chen MH, Chen YL, Bai YM, Huang KL, Wu HJ, Hsu JW, Su TP, Tsai SJ, Tu PC, Li CT, Lin WC, Wu YT (2020) Functional connectivity of specific brain networks related to social and communication dysfunction in adolescents with attention-deficit hyperactivity disorder. Psychiatry research 284:112785. doi:10.1016/j.psychres.2020.112785
62. Chen MH, Chang WC, Lin WC, Tu PC, Li CT, Bai YM, Tsai SJ, Huang WS, Su TP (2020) Functional Dysconnectivity of Frontal Cortex to Striatum Predicts Ketamine Infusion Response in Treatment-Resistant Depression. The international journal of neuropsychopharmacology 23 (12):791-798. doi:10.1093/ijnp/pyaa056
63. Chen MH, Chang WC, Bai YM, Huang KL, Tu PC, Su TP, Li CT, Lin WC, Tsai SJ, Hsu JW (2020) Cortico-thalamic dysconnection in early-stage schizophrenia: a functional connectivity magnetic resonance imaging study. European archives of psychiatry and clinical neuroscience 270 (3):351-358. doi:10.1007/s00406-019-01003-2
64. Chen IC, Kuo PH, Yang AC, Tsai SJ, Liu TH, Liu HJ, Lan TH, Chen HM, Huang HN, Chung RH, Liu YL (2020) CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption. Scientific reports 10 (1):18118. doi:10.1038/s41598-020-75199-y
65. Chang YW, Tsai SJ, Wu YF, Yang AC (2020) Development of an Al-Based Web Diagnostic System for Phenotyping Psychiatric Disorders. Frontiers in psychiatry 11:542394. doi:10.3389/fpsyt.2020.542394
66. Chan YE, Chen MH, Tsai SJ, Bai YM, Tsai CF, Cheng CM, Su TP, Chang WH, Chen TJ, Li CT (2020) Treatment-Resistant depression enhances risks of dementia and alzheimer's disease: A nationwide longitudinal study. Journal of affective disorders 274:806-812. doi:10.1016/j.jad.2020.05.150
67. Bai YM, Chen MH, Hsu JW, Huang KL, Tu PC, Chang WC, Su TP, Li CT, Lin WC, Tsai SJ (2020) A comparison study of metabolic profiles, immunity, and brain gray matter volumes between patients with bipolar disorder and depressive disorder. Journal of neuroinflammation 17 (1):42. doi:10.1186/s12974-020-1724-9
68. Wei HT, Pan TL, Hsu JW, Huang KL, Bai YM, Ko NY, Su TP, Li CT, Tsai SJ, Lin WC, Chen TJ, Chen MH (2019) Risks of bipolar disorder, depressive disorder, and traumatic brain injury among siblings of patients with attention-deficit hyperactivity disorder. Journal of affective disorders 245:335-339. doi:10.1016/j.jad.2018.11.057
69. Tu TH, Huang KL, Bai YM, Hsu JW, Su TP, Li CT, Tsai SJ, Lin WC, Chen TJ, Chen MH (2019) Exposure to Second-Generation Antipsychotics and Risk of Type 2 Diabetes Mellitus in Adolescents and Young Adults: A Nationwide Study in Taiwan. The Journal of clinical psychiatry 80 (2). doi:10.4088/JCP.18m12284
70. Tsao WY, Hsu JW, Huang KL, Bai YM, Su TP, Li CT, Tsai SJ, Lin WC, Chen TJ, Pan TL, Chen MH (2019) Risk of cardiometabolic diseases among siblings of patients with bipolar disorder. Journal of affective disorders 253:171-175. doi:10.1016/j.jad.2019.04.094
71. Tsai SJ (2019) Huperzine-A, a versatile herb, for the treatment of Alzheimer's disease. Journal of the Chinese Medical Association : JCMA 82 (10):750-751. doi:10.1097/jcma.0000000000000151
72. Tsai SJ (2019) Aged garlic extract supplement helps relieve acute stress. Journal of the Chinese Medical Association : JCMA 82 (9):677-678. doi:10.1097/jcma.0000000000000142
73. Lin WY, Huang CC, Liu YL, Tsai SJ, Kuo PH (2019) Polygenic approaches to detect gene-environment interactions when external information is unavailable. Briefings in bioinformatics 20 (6):2236-2252. doi:10.1093/bib/bby086
74. Lin WY, Chan CC, Liu YL, Yang AC, Tsai SJ, Kuo PH (2019) Performing different kinds of physical exercise differentially attenuates the genetic effects on obesity measures: Evidence from 18,424 Taiwan Biobank participants. PLoS genetics 15 (8):e1008277. doi:10.1371/journal.pgen.1008277
75. Lin E, Tsai SJ (2019) Epigenetics and Depression: An Update. Psychiatry investigation 16 (9):654-661. doi:10.30773/pi.2019.07.17.2
76. Lin E, Tsai SJ (2019) Machine Learning in Neural Networks. Advances in experimental medicine and biology 1192:127-137. doi:10.1007/978-981-32-9721-0_7
77. Lin E, Kuo PH, Liu YL, Yang AC, Tsai SJ (2019) Polymorphisms of the DNA repair gene EXO1 modulate cognitive aging in old adults in a Taiwanese population. DNA repair 78:1-6. doi:10.1016/j.dnarep.2019.03.013
78. Lin E, Kuo PH, Liu YL, Yang AC, Tsai SJ (2019) Association and Interaction Effects of Interleukin-12 Related Genes and Physical Activity on Cognitive Aging in Old Adults in the Taiwanese Population. Frontiers in neurology 10:1065. doi:10.3389/fneur.2019.01065
79. Li CT, Huang YZ, Bai YM, Tsai SJ, Su TP, Cheng CM (2019) Critical role of glutamatergic and GABAergic neurotransmission in the central mechanisms of theta-burst stimulation. Human brain mapping 40 (6):2001-2009. doi:10.1002/hbm.24485
80. Hung YH, Cheng CM, Lin WC, Bai YM, Su TP, Li CT, Tsai SJ, Pan TL, Chen TJ, Chen MH (2019) Post-traumatic stress disorder and asthma risk: A nationwide longitudinal study. Psychiatry research 276:25-30. doi:10.1016/j.psychres.2019.04.014
81. Huang MH, Cheng CM, Huang KL, Hsu JW, Bai YM, Su TP, Li CT, Tsai SJ, Lin WC, Chen TJ, Chen MH (2019) Bipolar disorder and risk of Parkinson disease: A nationwide longitudinal study. Neurology 92 (24):e2735-e2742. doi:10.1212/wnl.0000000000007649
82. Huang MH, Chen MH, Huang KL, Hsu JW, Bai YM, Cheng CM, Su TP, Li CT, Tsai SJ, Lin WC, Yang AC, Chen TJ (2019) Increased risk of type 2 diabetes among the siblings of patients with schizophrenia. CNS spectrums 24 (4):453-459. doi:10.1017/s1092852918001396
83. Hsu CL, Tsai SJ, Shen CC, Lu T, Hung YM, Hu LY (2019) Risk of benign paroxysmal positional vertigo in patients with depressive disorders: a nationwide population-based cohort study. BMJ open 9 (3):e026936. doi:10.1136/bmjopen-2018-026936
84. Gong W, Cheng F, Rolls ET, Lo CZ, Huang CC, Tsai SJ, Yang AC, Lin CP, Feng J (2019) A powerful and efficient multivariate approach for voxel-level connectome-wide association studies. NeuroImage 188:628-641. doi:10.1016/j.neuroimage.2018.12.032
85. Chu HT, Tseng CC, Liang CS, Yeh TC, Hu LY, Yang AC, Tsai SJ, Shen CC (2019) Risk of Depressive Disorders Following Myasthenia Gravis: A Nationwide Population-Based Retrospective Cohort Study. Frontiers in psychiatry 10:481. doi:10.3389/fpsyt.2019.00481
86. Cheng CM, Chang WH, Chiu YC, Chen MH, Liao WT, Yang CH, Hwang JP, Li CT, Bai YM, Tsai SJ, Chen TJ, Tsai CF (2019) Risk Score for Predicting Mortality in People With Dementia: A Nationwide, Population-Based Cohort Study in Taiwan With 11 Years of Follow-Up. The Journal of clinical psychiatry 80 (4). doi:10.4088/JCP.18m12629
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270. Hwang JP, Lee TW, Tsai SJ, Chen TJ, Yang CH, Lirng JF, Tsai CF (2010) Cortical and subcortical abnormalities in late-onset depression with history of suicide attempts investigated with MRI and voxel-based morphometry. Journal of geriatric psychiatry and neurology 23 (3):171-184. doi:10.1177/0891988710363713
271. Huang SC, Tsai SJ, Yang HJ (2010) Aripiprazole improves social interaction in Taiwanese children with pervasive developmental disorder. Chang Gung medical journal 33 (2):211-215
272. Hsu CD, Tsai SJ (2010) The tissue plasminogen activator/plasmin system may act through cleavage of pro-BDNF to increase risk of substance abuse. CNS spectrums 15 (6):350. doi:10.1017/s1092852900000328
273. Hong CJ, Tsai PJ, Cheng CY, Chou CK, Jheng HF, Chuang YC, Yang CN, Lin YT, Hsu CW, Cheng IH, Chen SY, Tsai SJ, Liou YJ, Tsai YS (2010) ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin. PloS one 5 (12):e15333. doi:10.1371/journal.pone.0015333
274. Hong CJ, Liou YJ, Bai YM, Chen TT, Wang YC, Tsai SJ (2010) Dopamine receptor D2 gene is associated with weight gain in schizophrenic patients under long-term atypical antipsychotic treatment. Pharmacogenetics and genomics 20 (6):359-366. doi:10.1097/FPC.0b013e3283397d06
275. Fukumoto N, Fujii T, Combarros O, Kamboh MI, Tsai SJ, Matsushita S, Nacmias B, Comings DE, Arboleda H, Ingelsson M, Hyman BT, Akatsu H, Grupe A, Nishimura AL, Zatz M, Mattila KM, Rinne J, Goto Y, Asada T, Nakamura S, Kunugi H (2010) Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 153b (1):235-242. doi:10.1002/ajmg.b.30986
276. Tsai SJ, Hong CJ, Liou YJ, Yu YW, Chen TJ, Hou SJ, Yen FC (2009) Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response. Progress in neuro-psychopharmacology & biological psychiatry 33 (4):637-641. doi:10.1016/j.pnpbp.2009.02.020
277. Tsai SJ, Hong CJ, Liou YJ, Chen TJ, Chen ML, Hou SJ, Yen FC, Yu YW (2009) Haplotype analysis of single nucleotide polymorphisms in the vascular endothelial growth factor (VEGFA) gene and antidepressant treatment response in major depressive disorder. Psychiatry research 169 (2):113-117. doi:10.1016/j.psychres.2008.06.028
278. Tsai SJ, Gau YT, Hong CJ, Liou YJ, Yu YW, Chen TJ (2009) Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism on clinical response to fluoxetine in major depressive patients. Journal of affective disorders 113 (1-2):183-187. doi:10.1016/j.jad.2008.04.017
279. Tsai SJ (2009) Statins may act through increasing tissue plasminogen activator/plasmin activity to lower risk of Alzheimer's disease. CNS spectrums 14 (5):234-235. doi:10.1017/s1092852900025360
280. Su KP, Chang HC, Tsai SJ, Yen FC, Tang CH (2009) Relapse and long-acting injectable risperidone: a 1-year mirror image study with a national claims database in Taiwan. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 12 Suppl 3:S118-121. doi:10.1111/j.1524-4733.2009.00643.x
281. Liu ME, Tsai SJ, Yang ST (2009) Varenicline-induced mixed mood and psychotic episode in a patient with Schizoaffective Disorder. CNS spectrums 14 (7):346. doi:10.1017/s1092852900022975
282. Liou YJ, Chen TJ, Tsai SJ, Yu YW, Cheng CY, Hong CJ (2009) Support for the involvement of the KCNK2 gene in major depressive disorder and response to antidepressant treatment. Pharmacogenetics and genomics 19 (10):735-741. doi:10.1097/FPC.0b013e32832cbe61
283. Lin E, Hong CJ, Hwang JP, Liou YJ, Yang CH, Cheng D, Tsai SJ (2009) Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression. Rejuvenation research 12 (6):387-393. doi:10.1089/rej.2009.0871
284. Hwang JP, Tsai SJ, Hong CJ, Yang CH, Hsu CD, Liou YJ (2009) Interleukin-1 beta -511C/T genetic polymorphism is associated with age of onset of geriatric depression. Neuromolecular medicine 11 (4):322-327. doi:10.1007/s12017-009-8078-x
285. Hou SJ, Yen FC, Tsai SJ (2009) Is dysfunction of the tissue plasminogen activator (tPA)-plasmin pathway a link between major depression and cardiovascular disease? Medical hypotheses 72 (2):166-168. doi:10.1016/j.mehy.2008.09.009
286. Cheng D, Tsai SJ, Hong CJ, Yang AC (2009) Reduced physiological complexity in robust elderly adults with the APOE epsilon4 allele. PloS one 4 (11):e7733. doi:10.1371/journal.pone.0007733
287. Chang HC, Tang CH, Tsai SJ, Yen FC, Su KP (2009) Long-acting injectable risperidone and hospital readmission: a mirror-image study using a national claim-based database in Taiwan. The Journal of clinical psychiatry 70 (1):141. doi:10.4088/jcp.08l04447
288. Yeh HL, Tsai SJ (2008) Lithium may be useful in the prevention of Alzheimer's disease in individuals at risk of presenile familial Alzheimer's disease. Medical hypotheses 71 (6):948-951. doi:10.1016/j.mehy.2008.03.049
289. Yang AC, Tsai SJ, Hong CJ, Yang CH, Hsieh CH, Liu ME (2008) Association between heart rate variability and cognitive function in elderly community-dwelling men without dementia: a preliminary report. Journal of the American Geriatrics Society 56 (5):958-960. doi:10.1111/j.1532-5415.2008.01662.x
290. Wang YC, Chen JY, Chen ML, Chen CH, Lai IC, Chen TT, Hong CJ, Tsai SJ, Liou YJ (2008) Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population. Biological psychiatry 64 (12):1093-1096. doi:10.1016/j.biopsych.2008.07.012
291. Tzang RF, Hong CJ, Liou YJ, Yu YW, Chen TJ, Tsai SJ (2008) Association study of p11 gene with major depressive disorder, suicidal behaviors and treatment response. Neuroscience letters 447 (1):92-95. doi:10.1016/j.neulet.2008.09.063
292. Tsai SJ, Liou YJ, Hong CJ, Yu YW, Chen TJ (2008) Glycogen synthase kinase-3beta gene is associated with antidepressant treatment response in Chinese major depressive disorder. The pharmacogenomics journal 8 (6):384-390. doi:10.1038/sj.tpj.6500486
293. Tsai SJ, Hong CJ, Liou YJ, Yu YW, Chen TJ (2008) Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response. Pharmacogenetics and genomics 18 (10):869-875. doi:10.1097/FPC.0b013e328308bbc0
294. Tsai SJ, Hong CJ, Liou YJ (2008) Brain-derived neurotrophic factor and antidepressant action: another piece of evidence from pharmacogenetics. Pharmacogenomics 9 (9):1353-1358. doi:10.2217/14622416.9.9.1353
295. Tsai SJ, Gau YT, Liu ME, Hsieh CH, Liou YJ, Hong CJ (2008) Association study of brain-derived neurotrophic factor and apolipoprotein E polymorphisms and cognitive function in aged males without dementia. Neuroscience letters 433 (2):158-162. doi:10.1016/j.neulet.2007.12.057
296. Tsai SJ (2008) Sipatrigine could have therapeutic potential for major depression and bipolar depression through antagonism of the two-pore-domain K+ channel TREK-1. Medical hypotheses 70 (3):548-550. doi:10.1016/j.mehy.2007.06.030
297. Shieh CH, Hong CJ, Huang YH, Tsai SJ (2008) Potential antidepressant properties of cysteamine on hippocampal BDNF levels and behavioral despair in mice. Progress in neuro-psychopharmacology & biological psychiatry 32 (6):1590-1594. doi:10.1016/j.pnpbp.2008.06.003
298. Liu ME, Hong CJ, Liou YJ, Tsai YL, Hsieh CH, Tsai SJ (2008) Association study of a functional catechol-O-methyltransferase polymorphism and executive function in elderly males without dementia. Neuroscience letters 436 (2):193-195. doi:10.1016/j.neulet.2008.03.018
299. Lin WC, Tsao JH, Tsai SJ (2008) Delayed thrombocytopenia after valproic acid overdose. General hospital psychiatry 30 (5):489-490. doi:10.1016/j.genhosppsych.2008.03.002
300. Li CT, Tsai SJ, Hwang JP (2008) Pramipexole-induced psychosis in Parkinson's disease. Psychiatry and clinical neurosciences 62 (2):245. doi:10.1111/j.1440-1819.2008.01766.x
301. Gau YT, Liou YJ, Yu YW, Chen TJ, Lin MW, Tsai SJ, Hong CJ (2008) Evidence for association between genetic variants of p75 neurotrophin receptor (p75NTR) gene and antidepressant treatment response in Chinese major depressive disorder. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 147b (5):594-599. doi:10.1002/ajmg.b.30646
302. Gau YT, Hong CJ, Tsai SJ (2008) Can antidepressants act as potential pro-neoplastic agents in patients with neurotrophic factor-related cancers? CNS spectrums 13 (10):849-850. doi:10.1017/s1092852900016941
303. Tsai SJ, Liou YJ, Liao DL, Cheng CY, Hong CJ (2007) No association of GRIP1 gene polymorphisms with schizophrenia in Chinese population. Progress in neuro-psychopharmacology & biological psychiatry 31 (3):752-755. doi:10.1016/j.pnpbp.2007.01.015
304. Tsai SJ, Hong CJ, Liou YJ, Liao DL (2007) Association study of GOT2 genetic polymorphisms and schizophrenia. Psychiatric genetics 17 (5):314. doi:10.1097/YPG.0b013e3280ae6cec
305. Tsai SJ, Hong CJ, Cheng CY, Liao DL, Liou YJ (2007) Association study of polymorphisms in post-synaptic density protein 95 (PSD-95) with schizophrenia. Journal of neural transmission (Vienna, Austria : 1996) 114 (4):423-426. doi:10.1007/s00702-006-0587-2
306. Tsai SJ, Hong CJ, Chen TJ, Yu YW (2007) Lack of supporting evidence for a genetic association of the FKBP5 polymorphism and response to antidepressant treatment. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 144b (8):1097-1098. doi:10.1002/ajmg.b.30246
307. Tsai SJ (2007) Increased central brain-derived neurotrophic factor activity could be a risk factor for substance abuse: Implications for treatment. Medical hypotheses 68 (2):410-414. doi:10.1016/j.mehy.2006.05.035
308. Tsai SJ (2007) The P11, tPA/plasminogen system and brain-derived neurotrophic factor: Implications for the pathogenesis of major depression and the therapeutic mechanism of antidepressants. Medical hypotheses 68 (1):180-183. doi:10.1016/j.mehy.2006.06.005
309. Tsai SJ (2007) TrkB partial agonists: potential treatment strategy for major depression. Medical hypotheses 68 (3):674-676. doi:10.1016/j.mehy.2006.06.019
310. Tsai SJ (2007) Attention-deficit hyperactivity disorder may be associated with decreased central brain-derived neurotrophic factor activity: clinical and therapeutic implications. Medical hypotheses 68 (4):896-899. doi:10.1016/j.mehy.2006.06.025
311. Tsai SJ (2007) Zinc sulfate could be potential agent for the treatment of Rett syndrome through increasing central BDNF levels. Medical hypotheses 68 (1):230-231. doi:10.1016/j.mehy.2006.07.006
312. Tsai SJ (2007) Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome. Medical hypotheses 68 (5):1144-1146. doi:10.1016/j.mehy.2006.07.017
313. Tsai SJ (2007) Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depression. Medical hypotheses 68 (6):1296-1299. doi:10.1016/j.mehy.2006.09.043
314. Tsai SJ (2007) Glatiramer acetate could be a potential antidepressant through its neuroprotective and anti-inflammatory effects. Medical hypotheses 69 (1):145-148. doi:10.1016/j.mehy.2006.10.051
315. Tsai SJ (2007) Glatiramer acetate could be a potential therapeutic agent for Parkinson's disease through its neuroprotective and anti-inflammatory effects. Medical hypotheses 69 (6):1219-1221. doi:10.1016/j.mehy.2007.04.014
316. Tsai CF, Tsai SJ, Yang CH, Hwang JP (2007) Chinese demented inpatients admitted following a suicide attempt: a case series. International journal of geriatric psychiatry 22 (11):1106-1109. doi:10.1002/gps.1795
317. Lin CC, Bai YM, Liu CY, Hsiao MC, Chen JY, Tsai SJ, Ouyang WC, Wu CH, Li YC (2007) Web-based tools can be used reliably to detect patients with major depressive disorder and subsyndromal depressive symptoms. BMC psychiatry 7:12. doi:10.1186/1471-244x-7-12
318. Hong CJ, Liou YJ, Liao DL, Hou SJ, Yen FC, Tsai SJ (2007) Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry 31 (7):1510-1513. doi:10.1016/j.pnpbp.2007.07.010
319. Yu YW, Tsai SJ, Liou YJ, Hong CJ, Chen TJ (2006) Association study of two serotonin 1A receptor gene polymorphisms and fluoxetine treatment response in Chinese major depressive disorders. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 16 (7):498-503. doi:10.1016/j.euroneuro.2005.12.004
320. Tsai SJ, Hong CJ, Liu HC, Liu TY, Liou YJ (2006) The brain-derived neurotrophic factor gene as a possible susceptibility candidate for Alzheimer's disease in a chinese population. Dementia and geriatric cognitive disorders 21 (3):139-143. doi:10.1159/000090673
321. Tsai SJ, Hong CJ, Liao DL, Chiang CH (2006) Distribution of androgen receptor CAG repeat polymorphism in Chinese schizophrenia and its correlation with age at onset. Psychoneuroendocrinology 31 (2):270-274. doi:10.1016/j.psyneuen.2005.06.006
322. Tsai SJ, Hong CJ, Hou SJ, Yen FC (2006) Association study of adenosine A2a receptor (1976C>T) genetic polymorphism and mood disorders and age of onset. Psychiatric genetics 16 (5):185. doi:10.1097/01.ypg.0000218627.26622.eb
323. Tsai SJ, Cheng CY, Hong CJ, Liao DL, Liou YJ (2006) Polymorphisms in glycine transporter with schizophrenia. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 8 (1):17-21
324. Tsai SJ, Cheng CY, Hong CJ, Liao DL, Hou SJ, Yen FC, Liou YJ (2006) Association study of polymorphisms in glycine transporter with schizophrenia. Journal of neural transmission (Vienna, Austria : 1996) 113 (10):1545-1549. doi:10.1007/s00702-006-0438-1
325. Tsai SJ (2006) TrkB partial agonists: potential treatment strategy for epilepsy, mania, and autism. Medical hypotheses 66 (1):173-175. doi:10.1016/j.mehy.2005.05.033
326. Tsai SJ (2006) The possible role of tissue-type plasminogen activator and the plasminogen system in the pathogenesis of major depression. Medical hypotheses 66 (2):319-322. doi:10.1016/j.mehy.2005.10.009
327. Tsai SJ (2006) Deltamethrin, a pyrethroid insecticide, could be a potential antidepressant agent. Medical hypotheses 66 (3):605-608. doi:10.1016/j.mehy.2005.10.011
328. Tsai SJ (2006) Lithium and antidepressants: potential agents for the treatment of Rett syndrome. Medical hypotheses 67 (3):626-629. doi:10.1016/j.mehy.2006.02.029
329. Tsai SJ (2006) Cysteamine-related agents could be potential antidepressants through increasing central BDNF levels. Medical hypotheses 67 (5):1185-1188. doi:10.1016/j.mehy.2006.05.005
330. Tsai SJ (2006) Signal transducer and activator of transcription 6 (STAT6) and attention-deficit hyperactivity disorder: a speculative hypothesis. Medical hypotheses 67 (6):1342-1344. doi:10.1016/j.mehy.2006.05.019
331. Hwang JP, Yang CH, Hong CJ, Lirng JF, Yang YM, Tsai SJ (2006) Association of APOE genetic polymorphism with cognitive function and suicide history in geriatric depression. Dementia and geriatric cognitive disorders 22 (4):334-338. doi:10.1159/000095599
332. Hwang JP, Tsai SJ, Hong CJ, Yang CH, Lirng JF, Yang YM (2006) The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiology of aging 27 (12):1834-1837. doi:10.1016/j.neurobiolaging.2005.10.013
333. Hong CJ, Hou SJ, Yen FC, Liou YJ, Tsai SJ (2006) Family-based association study between G72/G30 genetic polymorphism and schizophrenia. Neuroreport 17 (10):1067-1069. doi:10.1097/01.wnr.0000224763.61959.26
334. Hong CJ, Chen TJ, Yu YW, Tsai SJ (2006) Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. The pharmacogenomics journal 6 (1):27-33. doi:10.1038/sj.tpj.6500340
335. Cheng D, Hong CJ, Liao DL, Tsai SJ (2006) Association study of androgen receptor CAG repeat polymorphism and male violent criminal activity. Psychoneuroendocrinology 31 (4):548-552. doi:10.1016/j.psyneuen.2005.11.004
336. Yu YW, Yang CW, Wu HC, Tsai SJ, Hong CJ, Chen MC, Chen TJ (2005) Association study of a functional MAOA-uVNTR gene polymorphism and personality traits in Chinese young females. Neuropsychobiology 52 (3):118-121. doi:10.1159/000087556
337. Yu YW, Tsai SJ, Hong CJ, Chen TJ, Chen MC, Yang CW (2005) Association study of a monoamine oxidase a gene promoter polymorphism with major depressive disorder and antidepressant response. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 30 (9):1719-1723. doi:10.1038/sj.npp.1300785
338. Yu YW, Tsai SJ, Hong CJ, Chen MC, Yang CW, Chen TJ (2005) Association study of a functional MAOA-uVNTR gene polymorphism and cognitive function in healthy females. Neuropsychobiology 52 (2):77-82. doi:10.1159/000086609
339. Yu YW, Chen TJ, Chen MC, Tsai SJ, Lee TW (2005) Effect of age and global function score on schizophrenic p300 characteristics. Neuropsychobiology 51 (1):45-52. doi:10.1159/000082855
340. Yang CH, Tsai SJ, Hwang JP (2005) The efficacy and safety of quetiapine for treatment of geriatric psychosis. Journal of psychopharmacology (Oxford, England) 19 (6):661-666. doi:10.1177/0269881105056669
341. Tsai SJ, Liao DL, Yu YW, Chen TJ, Wu HC, Lin CH, Cheng CY, Hong CJ (2005) A study of the association of (Val66Met) polymorphism in the brain-derived neurotrophic factor gene with alcohol dependence and extreme violence in Chinese males. Neuroscience letters 381 (3):340-343. doi:10.1016/j.neulet.2005.02.043
342. Tsai SJ (2005) Adenosine A2a receptor/dopamine D2 receptor hetero-oligomerization: a hypothesis that may explain behavioral sensitization to psychostimulants and schizophrenia. Medical hypotheses 64 (1):197-200. doi:10.1016/j.mehy.2004.04.018
343. Tsai SJ (2005) Could repetitive transcranial magnetic stimulation be effective in autism? Medical hypotheses 64 (5):1070-1071. doi:10.1016/j.mehy.2004.11.025
344. Tsai SJ (2005) Is autism caused by early hyperactivity of brain-derived neurotrophic factor? Medical hypotheses 65 (1):79-82. doi:10.1016/j.mehy.2005.01.034
345. Tsai SJ (2005) Possible involvement of brain-derived neurotrophic factor in the antinociceptive effect of antidepressants in neuropathic pain. Medical hypotheses 65 (3):530-533. doi:10.1016/j.mehy.2005.03.021
346. Tsai SJ (2005) Asthma, major depression and brain-derived neurotrophic factor. Medical hypotheses 65 (2):417-418. doi:10.1016/j.mehy.2005.03.003
347. Tsai SJ (2005) Strategies to increase central N-acetyl aspartylglutamate: a potential treatment for schizophrenia and bipolar disorders. Schizophrenia research 76 (2-3):359-360. doi:10.1016/j.schres.2004.12.018
348. Tsai SJ (2005) The novel atypical antipsychotic aripiprazole as treatment for and prophylaxis against progressive multifocal leukoencephalopathy. Medical hypotheses 65 (3):633-634. doi:10.1016/j.mehy.2005.04.012
349. Tsai SJ (2005) Possible involvement of the BDNF-dependent pathway in treatment-emergent suicidality or decreased response to antidepressants. Medical hypotheses 65 (5):942-946. doi:10.1016/j.mehy.2005.05.010
350. Tsai SJ (2005) Repetitive transcranial magnetic stimulation: a possible novel therapeutic approach to eating disorders. Medical hypotheses 65 (6):1176-1178. doi:10.1016/j.mehy.2005.05.020
351. Tsai SJ (2005) Central N-acetyl aspartylglutamate deficit: a possible pathogenesis of schizophrenia. Medical science monitor : international medical journal of experimental and clinical research 11 (9):Hy39-45
352. Tsai CF, Tsai SJ, Hwang JP (2005) Ziprasidone-induced hypersensitivity syndrome in an aged schizophrenia patient. International journal of geriatric psychiatry 20 (8):797-799. doi:10.1002/gps.1346
353. Liu HC, Hong CJ, Liu TY, Tsai SJ (2005) Association analysis of adenosine A2a receptor 1976T>C polymorphisms and Alzheimer's disease. European neurology 53 (2):99-100. doi:10.1159/000085509
354. Liu HC, Hong CJ, Liu TY, Chi CW, Tsai SJ (2005) Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease. Dementia and geriatric cognitive disorders 19 (1):42-45. doi:10.1159/000080970
355. Lee TW, Yu YW, Chen TJ, Tsai SJ (2005) Loudness dependence of the auditory evoked potential and response to antidepressants in Chinese patients with major depression. Journal of psychiatry & neuroscience : JPN 30 (3):202-205
356. Lam P, Hong CJ, Tsai SJ (2005) Association study of A2a adenosine receptor genetic polymorphism in panic disorder. Neuroscience letters 378 (2):98-101. doi:10.1016/j.neulet.2004.12.012
357. Hong CJ, Yu YW, Chen TJ, Tsai SJ (2005) Interleukin-6 genetic polymorphism and Chinese major depression. Neuropsychobiology 52 (4):202-205. doi:10.1159/000089003
358. Hong CJ, Liu HC, Liu TY, Liao DL, Tsai SJ (2005) Association studies of the adenosine A2a receptor (1976T > C) genetic polymorphism in Parkinson's disease and schizophrenia. Journal of neural transmission (Vienna, Austria : 1996) 112 (11):1503-1510. doi:10.1007/s00702-005-0286-4
359. Cheng CY, Hong CJ, Yu YW, Chen TJ, Wu HC, Tsai SJ (2005) Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. Brain research Molecular brain research 140 (1-2):86-90. doi:10.1016/j.molbrainres.2005.07.008
360. Cheng CY, Hong CJ, Tsai SJ (2005) Effects of subchronic clozapine administration on serum glucose, cholesterol and triglyceride levels, and body weight in male BALB/c mice. Life sciences 76 (19):2269-2273. doi:10.1016/j.lfs.2004.12.004
361. Chen TJ, Yu YW, Chen MC, Wang SY, Tsai SJ, Lee TW (2005) Serotonin dysfunction and suicide attempts in major depressives: an auditory event-related potential study. Neuropsychobiology 52 (1):28-36. doi:10.1159/000086175
362. Yu YW, Tsai SJ, Hong CJ, Chen TJ, Yang CW (2004) Association analysis for MAOA gene polymorphism with long-latency auditory evoked potentials in healthy females. Neuropsychobiology 50 (4):288-291. doi:10.1159/000080954
363. Tsai SJ, Yu YW, Lin CH, Wang YC, Chen JY, Hong CJ (2004) Association study of adrenergic beta3 receptor (Trp64Arg) and G-protein beta3 subunit gene (C825T) polymorphisms and weight change during clozapine treatment. Neuropsychobiology 50 (1):37-40. doi:10.1159/000077939
364. Tsai SJ, Yu YW, Hong CJ (2004) Personality traits in young female apolipoprotein E (apoE) epsilon4 and non-epsilon4 carriers. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 124b (1):58-60. doi:10.1002/ajmg.b.20052
365. Tsai SJ, Hong CJ, Yu YW, Chen TJ, Wang YC, Lin WK (2004) Association study of serotonin 1B receptor (A-161T) genetic polymorphism and suicidal behaviors and response to fluoxetine in major depressive disorder. Neuropsychobiology 50 (3):235-238. doi:10.1159/000079977
366. Tsai SJ, Hong CJ, Yu YW, Chen TJ (2004) Association study of a brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and personality trait and intelligence in healthy young females. Neuropsychobiology 49 (1):13-16. doi:10.1159/000075333
367. Tsai SJ, Hong CJ, Yu YW, Chen TJ (2004) Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young chinese females. Neuropsychobiology 50 (2):153-156. doi:10.1159/000079107
368. Tsai SJ, Hong CJ, Liu HC, Liu TY, Hsu LE, Lin CH (2004) Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobiology 49 (1):10-12. doi:10.1159/000075332
369. Tsai SJ, Hong CJ, Liao DL, Lai IC, Liou YJ (2004) Association study of a functional catechol-O-methyltransferase genetic polymorphism with age of onset, cognitive function, symptomatology and prognosis in chronic schizophrenia. Neuropsychobiology 49 (4):196-200. doi:10.1159/000077366
370. Tsai SJ (2004) Is mania caused by overactivity of central brain-derived neurotrophic factor? Medical hypotheses 62 (1):19-22. doi:10.1016/s0306-9877(03)00297-4
371. Tsai SJ (2004) Down-regulation of the Trk-B signal pathway: the possible pathogenesis of major depression. Medical hypotheses 62 (2):215-218. doi:10.1016/s0306-9877(03)00299-8
372. Tsai SJ (2004) Dopamine receptor downregulation: an alternative strategy for schizophrenia treatment. Medical hypotheses 63 (6):1047-1050. doi:10.1016/j.mehy.2004.04.012
373. Liao DL, Hong CJ, Shih HL, Tsai SJ (2004) Possible association between serotonin transporter promoter region polymorphism and extremely violent crime in Chinese males. Neuropsychobiology 50 (4):284-287. doi:10.1159/000080953
374. Lam P, Cheng CY, Hong CJ, Tsai SJ (2004) Association study of a brain-derived neurotrophic factor (Val66Met) genetic polymorphism and panic disorder. Neuropsychobiology 49 (4):178-181. doi:10.1159/000077362
375. Kao CL, Huang SC, Yang YJ, Tsai SJ (2004) A case of parenteral zolpidem dependence with opioid-like withdrawal symptoms. The Journal of clinical psychiatry 65 (9):1287. doi:10.4088/jcp.v65n0918g
376. Hwang JP, Yang CH, Tsai SJ (2004) Comparison study of venlafaxine and paroxetine for the treatment of depression in elderly Chinese inpatients. International journal of geriatric psychiatry 19 (2):189-190. doi:10.1002/gps.1051
377. Huang YH, Cheng CY, Hong CJ, Tsai SJ (2004) Expression of c-Fos-like immunoreactivity in the brain of mice with learned helplessness. Neuroscience letters 363 (3):280-283. doi:10.1016/j.neulet.2004.04.011
378. Huang SC, Tsai SJ, Chang JC (2004) Fluoxetine-induced memory impairment in four family members. International journal of psychiatry in medicine 34 (2):197-200. doi:10.2190/dy6d-33bp-5wpb-1vdx
379. Hou SJ, Yen FC, Cheng CY, Tsai SJ, Hong CJ (2004) X-box binding protein 1 (XBP1) C--116G polymorphisms in bipolar disorders and age of onset. Neuroscience letters 367 (2):232-234. doi:10.1016/j.neulet.2004.06.012
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