United States Patent |
6,799,535 |
Hong |
October 5, 2004 |
Method and system for measuring mobility of a tested animal
Abstract
In a method and system for measuring mobility of a tested animal, a lower
float portion of a float member floats on a liquid body disposed in a container.
An upper detected portion of the float member vertically opposite to the lower
float portion is disposed above the liquid body. The tested animal is placed in
the liquid body such that movement of the tested animal in the liquid body
results in surface waves of the liquid body and that the upper, detected portion
moves according to the surface waves reaching the lower float portion. Positions
of the upper detected portion are optically detected during a time period.
Position information of the tested animal in the liquid body is then determined
from the detected positions.
Inventors: |
Hong; Chen-Jee (Taipei City, TW)
|
Appl. No.: |
10/408,177 |
Filed: |
April 4, 2003 |
Foreign Application Priority Data
|
|
|
|
|
Apr 19, 2002 [TW] |
|
|
91108088 A |
|
Current U.S. Class: |
119/421 |
Current International Class:
|
A01K 29/00 (20060101) |
Field of Search: |
119/174,417,421,452,908
|
References Cited [Referenced
By]
U.S. Patent Documents
Primary Examiner: Jordan;
Charles T.
Assistant Examiner: Shaw; Elizabeth
Attorney, Agent
or Firm: O'Connor; Christensen Johnson Kindness PLLC
Claims
I claim:
1. A method for measuring mobility of a tested animal,
comprising the steps of: a) providing a liquid body; b) providing a float member
having a lower float portion that floats on the liquid body, and an upper
detected portion that is vertically opposite to the lower float portion and that
is disposed above the liquid body; c) placing the tested animal in the liquid
body such that movement of the tested animal in the liquid body results in
surface waves of the liquid body and that the upper detected portion of the
float member moves according to the surface waves that reach the lower float
portion of the float member; d) optically detecting positions of the upper
detected portion of the float member during a time period; and e) determining
position information of the tested animal in the liquid body from the positions
detected in step d).
2. The method as claimed in claim 1, further
comprising the step of providing a barrier, which is disposed above a surface of
the liquid body, to prevent the tested animal in the liquid body from reaching
the lower float portion of the float member.
3. The method as claimed in
claim 1, wherein movement of the float member on the liquid body is restricted
such that range of movement of the upper detected portion is limited to within a
predetermined area.
4. The method as claimed in claim 1, wherein the
upper detected portion of the float member is movably confined within a sensing
region, and step d) includes projecting light into the sensing region, and
receiving light reflected by the upper detected portion in the sensing region.
5. The method as claimed in claim 4, wherein step d) is conducted using
an optical mouse.
6. The method as claimed in claim 5, wherein the
sensing region is cooperatively confined by a base plate, the optical mouse, and
a spacer that interconnects the base plate and the optical mouse.
7. The
method as claimed in claim 1, wherein the position information includes a
plurality of two-dimensional coordinate data.
8. The method as claimed
in claim 1, further comprising the step of displaying the position information
on a monitor.
9. The method as claimed in claim 1, further comprising
the step of storing the position information in a data storage medium.
10. A system for measuring mobility of a tested animal, comprising: a
container; a liquid body disposed in said container; a float member having a
lower float portion that floats on said liquid body, and an upper detected
portion that is vertically opposite to said lower float portion and that is
disposed above said liquid body, said upper detected portion of said float
member moving according to surface waves of said liquid body that result from
movement of the tested animal in said liquid body when the tested animal is
placed in said liquid body and that reach said lower float portion of said float
member; a sensor unit for optically detecting positions of said upper detected
portion of said float member during a time period; and a computing unit, coupled
to said sensor unit, for determining position information of the tested animal
in said liquid body from the positions detected by said sensor unit.
11.
The system as claimed in claim 10, wherein said container is formed with a
barrier disposed above a surface of said liquid body to prevent the tested
animal in said liquid body from reaching said lower float portion of said float
member.
12. The system as claimed in claim 11, wherein said barrier is
formed with a guide member to restrict movement of said float member on said
liquid body such that range of movement of said upper detected portion is
limited to within a predetermined area.
13. The system as claimed in
claim 12, wherein said upper detected portion of said float member is movably
confined within a sensing region of said sensor unit, said sensor unit
projecting light into said sensing region, and receiving light reflected by said
upper detected portion in said sensing region.
14. The system as claimed
in claim 13, wherein said sensor unit includes an optical mouse.
15. The
system as claimed in claim 14, wherein said sensor unit further includes a base
plate and a spacer that interconnects said base plate and said optical mouse,
said sensing region being cooperatively confined by said base plate, said
optical mouse, and said spacer.
16. The system as claimed in claim 10,
wherein the position information includes a plurality of two-dimensional
coordinate data.
17. The system as claimed in claim 10, wherein said
computing unit includes a monitor for displaying the position information
thereon.
18. The system as claimed in claim 10, wherein said computing
unit includes a data storage medium for storing the position information
therein.
19. The system as claimed in claim 10, further comprising a
temperature sensor disposed in said liquid body and coupled to said computing
unit, said temperature sensor sensing temperature of said liquid body in said
container and generating an output signal associated with the temperature of
said liquid body that is provided to said computing unit, and a heating unit
disposed in said liquid body and coupled to said computing unit, said computing
unit controlling said heating unit to supply heat to said liquid body in said
container according to the output signal from said temperature sensor so as to
control the temperature of said liquid body in said container within a
predetermined temperature range suitable for the tested animal.
Description
CROSS-REFERENCE TO RELATED APPLICATION
This application claims
priority of Taiwanese Application No. 091108088, filed on Apr. 19, 2002.
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a measuring system, more particularly to a
method and apparatus for measuring mobility of a tested animal.
2.
Description of the Related Art
A measurement result from the forced
swimming test for a tested animal, such as a mouse, is usually used as reference
for evaluating whether the tested animal has symptoms of depression.
FIG. 1 illustrates an automated system for measuring mobility of a
tested mouse 97 in the forced swimming test. The system includes a cylindrical
container 91, a liquid body 96 disposed in the container 91, a sensor unit 92, a
counter unit 93, a printer 95, and a control unit 94 coupled electrically to the
sensor 92, the counter unit 93 and the printer 95. Initially, the tested mouse
97 is placed in the liquid body 96 around an electromagnetic field with a
predetermined frequency. Movement of the tested mouse 97 in the liquid body 96
will result in variations in the frequency of the electromagnetic field relative
to the predetermined frequency. As such, the control unit 94 transforms
frequency variations sensed by the sensor unit 92 into voltage changes expressed
as impulses for receipt by the counter unit 93. The printer 95 prints the result
measured by the system.
The sensor unit 92, the counter unit 93, the
control unit 94 and the printer 95 are needed in the system, thereby resulting
in a relatively high cost. Moreover, the measurement result, i.e., the times of
mobility of the tested mouse 97, cannot be relied upon as reference for other
analyses.
SUMMARY OF THE INVENTION
Therefore, the object of the
present invention is to provide a relatively low cost method and apparatus for
measuring mobility of a tested animal.
According to one aspect of the
present invention, there is provided a method for measuring mobility of a tested
animal. The method comprises the steps of: a) providing a liquid body; b)
providing a float member having a lower float portion that floats on the liquid
body, and an upper detected portion that is vertically opposite to the lower
float portion and that is disposed above the liquid body; c) placing the tested
animal in the liquid body such that movement of the tested animal in the liquid
body results in surface waves of the liquid body and that the upper detected
portion of the float member moves according to the surface waves that reach the
lower float portion of the float member; d) optically detecting positions of the
upper detected portion of the float member during a time period; and e)
determining position information of the tested animal in the liquid body from
the positions detected in step d).
According to another aspect of the
present invention, there is provided a system for measuring mobility of a tested
animal. The system comprises: a container; a liquid body disposed in the
container; a float member having a lower float portion that floats on the liquid
body, and an upper detected portion that is vertically opposite to the lower
float portion and that is disposed above the liquid body, the upper detected
portion of the float member moving according to surface waves of the liquid body
that result from movement of the tested animal in the liquid body when the
tested animal is placed in the liquid body and that reach the lower float
portion of the float member; a sensor unit for optically detecting positions of
the upper detected portion of the float member during a time period; and a
computing unit, coupled to the sensor unit, for determining position information
of the tested animal in the liquid body from the positions detected by the
sensor unit.
BRIEF DESCRIPTION OF THE DRAWINGS
Other features
and advantages of the present invention will become apparent in the following
detailed description of the preferred embodiment with reference to the
accompanying drawings, of which:
FIG. 1 illustrates a conventional
system for measuring mobility of a tested animal;
FIG. 2 is a schematic
view showing the preferred embodiment of a system for measuring mobility of a
tested animal according to the present invention;
FIG. 3 is a
fragmentary schematic sectional view taken along line III--III in FIG. 2;
FIG. 4 is a fragmentary schematic sectional view taken along line IV--IV
in FIG. 2; and
FIG. 5 is a distribution plot of position information of
the tested animal shown on a monitor of the preferred embodiment.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
Referring to
FIG. 2, the preferred embodiment of a system for measuring mobility of a tested
animal 4 according to the present invention is shown to include a container 11,
a liquid body 12, a float member 21, a sensor unit 5, and a computing unit 6. In
this embodiment, the tested animal 4 is a mouse. The mobility result for the
tested animal 4 measured by the system can be used as reference for evaluating
melancholia or can be used for other purposes.
The container 11 is
cylindrical in shape. The liquid body 12, such as water, is disposed in the
container 11.
The float member 21 has a lower float portion 211 in the
shape of a ball that floats on the liquid body 12, and an upper detected portion
22 that is vertically opposite to the lower float portion 211 and that is
disposed above the liquid body 12. The upper detected portion 22 of the float
member 21 moves according to surface waves of the liquid body 12 that result
from movement of the tested animal 4 in the liquid body 12 when the tested
animal 4 is placed in the liquid body 12 and that reach the lower float portion
211 of the float member 21. In addition, the container 11 is formed with a
barrier 111 disposed above a surface of the liquid body 12 to prevent the tested
animal 4 in the liquid body 12 from reaching the lower float portion 211 of the
float member 21, as best shown in FIG. 2. The barrier 111 is formed with a
semicircular guide member 112 to restrict movement of the float member 21 on the
liquid body 12 such that range of movement of the upper detected portion 22 is
limited to within a predetermined area, as best shown in FIG. 3.
The
sensor unit 5 optically detects positions of the upper detected portion 22 of
the float member 21 during a time period. The upper detected portion 22 of the
float member 21 is movably confined within a sensing region 55 of the sensor
unit 5 (see FIG. 4). The sensor unit 5 includes a conventional optical mouse 53
that has a light emitter 532 projecting light into the sensing region 55 and
that receives light reflected by the upper detected portion 22 in the sensing
region 55. In this embodiment, the sensor unit 5 further includes a base plate
52, and a spacer 54 that interconnects the base plate 52 and the optical mouse
53. The sensing region 55 is cooperatively confined by the base plate 52 mounted
on the container 11 by means of a frame 51, the optical mouse 53 and the spacer
54, as best shown in FIG. 4.
The computing unit 6 is coupled to the
sensor unit 5 and determines position information of the tested animal 4 in the
liquid body 12 from the positions detected by the sensor unit 5. The position
information includes a plurality of two-dimensional coordinate data. In this
embodiment, the computing unit 6, such as a personal computer, includes a
monitor 63 for displaying the position information thereon (see FIG. 5), and a
data storage medium 62 for storing the position information therein. Therefore,
according to the position information, mobility velocity of the tested animal 4
during the time period can be obtained.
The system further includes a
temperature sensor 71 and a heating unit 72 (see FIG. 2). The temperature sensor
71 is disposed in the liquid body 12, is coupled to the computing unit 6, and
senses temperature of the liquid body 12 in the container 11 so as to generate
an output signal associated with the temperature of the liquid body 12 that is
provided to the computing unit 6. The heating unit 72 is disposed in the liquid
body 12 and is coupled to the computing unit 6. The computing unit 6 controls
the heating unit 72 to supply heat to the liquid body 12 in the container 11
according to the output signal from the temperature sensor 71 so as to control
the temperature of the liquid body 12 in the container 11 within a predetermined
temperature range suitable for the tested animal 4. In this embodiment, the
predetermined temperature range is 25-28.degree. C.
It is noted that,
due to the use of a personal computer and an optical mouse, the system of the
present invention can easily achieve measurement for mobility of a tested animal
at a relatively low cost.
While the present invention has been described
in connection with what is considered the most practical and preferred
embodiment, it is understood that this invention is not limited to the disclosed
embodiment but is intended to cover various arrangements included within the
spirit and scope of the broadest interpretation so as to encompass all such
modifications and equivalent arrangements.
* * * * *