行為與基因實驗室(PsyLab)

主 持 人：洪成志

研究興趣：

• 影響情緒與行為的分子遺傳機制

• 失智症的基因檢測與遺傳諮詢

• 建立模擬人類疾病精神疾病的動物模式(reference)

代表著作：

1. CJ Hong, HL Song, HC Lai, SJ Tsai, KJ Hsiao. Methanol/Acetone treatment helps the amplification of FMR1 CGG repeat fragment in dried blood spots from Guthrie cards. Lancet 353(9159):1153-1154, 3 April 1999.

2. Pei-Ning Wang, Chen-Jee Hong, Ker-Neng Lin, Hsiu-Chih Liu, Wei-Ta Chen. APOE ε4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer’s disease among ethnic Chinese in Taiwan. Journal of Neurology, Neurosurgery & Psychiatry 2011 Feb;82(2):165-9. (abstract)

3. Chen-Jee Hong, Pei-Jane Tsai^#, Chih-Ya Cheng, Chuan-Kai Chou, Huei-Fen Jheng, You-Chung Chuang, Chia-Ning Yang, Ya-Tzu Lin, Chih-Wei Hsu, Irene H. Cheng, Shiow-Yi Chen, Shih-Jen Tsai, Ying-Jay Liou, Yau-Sheng Tsai. ENU Mutagenesis Identifies Mice with Morbid Obesity and Severe Hyperinsulinemia Caused by a Novel Mutation in Leptin. PLoS One. 2010;5(12):e15333.(full article)

4. Ying-Jay Liou, Chien-Hsiun Chen, Chih-Ya Cheng, Shiow-Yi Chen, Tai-Jui Chen, Younger W-Y Yu, Fang-Shin Nian, Shih-Jen Tsai, Chen-Jee Hong*. Convergent Evidence from Mouse and Human Studies Suggests the Involvement of Zinc Finger Protein 326 Gene in Antidepressant Treatment Response. PLoS ONE 2012;7(5):e32984.(full article) 

5. Ying-Jay Liou, Hui-Hung Wang, Ming-Ta Michael Lee, Sheng-Chang Wang, Hung-Lun Chiang, Cheng-Chung Chen, Ching-Hua Lin, Ming-Shun Chung, Chien-Cheng Kuo, Ding-Lieh Liao, Ching-Kuan Wu, Chih-Min Liu, Yu-Li Liu, Hai-Gwo Hwu, I-Ching Lai, Shih-Jen Tsai, Chia-Hsiang Chen, Hui-Fen Liu, Yi-Chun Chou, Chien-Hsiun Chen, Yuan-Tsong Chen, Chen-Jee Hong*, and Jer-Yuarn Wu*. Genome-Wide Association Study of Treatment Refractory Schizophrenia in Han Chinese. PLoS ONE 2012;7(3):e33598. (full article)

6. 洪成志、廖敏華、王正如、鄭之雅：遺傳性失智症的基因檢測與諮詢(pdf)。台灣醫界 2011;54(9):10-18.

專利

• Hong CJ: Method and System for Measuring Motility of a Tested Animal. USA Invention Patent No.: US 6,799,535; Date of Patent: Oct. 5, 2004.
• Hong CJ: Tail suspension test apparatus. USA Invention Patent No.: US 6,955,139; Date of Patent: Oct. 18, 2005.
• Hong CJ: Method and system for evaluating interest of a tested animal. USA Invention Patent No.: US 7,121,229; Date of Patent: Oct. 17, 2006.

獎勵事項：

• 台北榮總醫療技術創新獎：1999 & 2004

執行計畫(名稱及經費來源)：

• 小鼠 Rab18 基因缺損導致小腦退化與殺嬰行為的分子病理研究 (國科會)

• 選殖小鼠遺傳性肥胖合併焦慮行為的基因 (國科會)

• 運動對小鼠的習得無助與腦部病理的影響 (台北榮總)

• 難治型精神分裂症之基因體關聯性研究計畫 (中研院)

未來方向：

• Rab18缺損造成神經軸突退化的機轉

• Leptin缺損、肥胖與運動對神經增生與情緒行為的影響

• 建立更快速與廣泛的篩檢家族性失智症基因突變的方法